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Previous studies have integrated genome‐wide association studies with expression quantitative trait locus (eQTL) data from bulk tissues to identify stroke susceptibility genes. However, eQTL data ...

Ongoing work in functional annotations of genomes has generated rich datasets. We propose a method to link extensive functional annotations to genotype-to-phenotype associations. This method ranks ...

Professor Cathy Fernandes is a behavioural geneticist and pharmacologist with more than 30 years’ experience working in rodent behaviour. She originally trained as a psychopharmacologist at Guy’s ...

Chromosomes in the eukaryotic nucleus are highly compacted. However, for many functional processes, including transcription initiation, the pairwise motion of distal chromosomal elements such as ...

Copyright: © 2023 The Author(s). Published by Elsevier B.V. Two new AD/dementia GWAS have dramatically expanded the sample sizes and the number of disease ...

Contributions: (I) Conception and design: Y Huang, L Cai, Q Xiang, R Yu; (II) Administrative support: Y Huang, L Cai, X Liu; (III) Provision of study materials or patients: Y Huang, L Cai, Y Wu; (IV) ...

Reversible CD8 T cell–neuron cross-talk causes aging-dependent neuronal regenerative decline Understanding and treating disease requires deep, systematic characterization of different cells and their ...

We describe a genome-wide analytical approach, SNP and Haplotype Regional Heritability Mapping (SNHap-RHM), that provides regional estimates of the heritability across locally defined regions in the ...

Freyman, W.A., Johnson, M.G., and C.J. Rothfels. 2022. Homologizer: phylogenetic phasing of gene copies into polyploid subgenomes. bioRxiv 2020.10.22.351486v4 Our first example analysis uses ...